Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.
Role Summary:
Spyre Therapeutics is seeking a highly strategic and hands-on commercial leader to shape the future commercial success of our lead assets across IBD and rheumatology as we advance from Phase 2 into Phase 3 and ultimately launch. This individual will serve as a key commercial leader in the company, integrating market access, commercial strategy, and early marketing insights to ensure the portfolio is positioned for optimal value, adoption, and access at launch.
This role requires a builder and strategic mindset, comfort with ambiguity, and the ability to influence cross-functional decisions that will define the product’s long-term commercial trajectory.
Key Responsibilities:
Market Access & Value Strategy
- Develop the global pricing strategy, including scenario planning, pricing corridors and gross-to-net assumptions
- Map evidence requirements and gaps to support global payer and HTA decision-making
- Build early payer engagement strategy and plan
- Assess patient support landscape and build launch strategy, inclusive of hub, call center, copay, nurse, and field reimbursement
- Develop US channel strategy for Spyre launch brands
- Determine optimal global launch waves and sequencing to optimize commercial value
- Regularly monitor global policy and pricing landscape changes and assess impact to Spyre portfolio
- Partner with competitive intelligence team to monitor competitor pricing and access dynamics and impact to Spyre
Commercial & Asset Strategy
- Partner with CCO and corporate strategy team to refine commercial strategy as Spyre clinical profiles solidify and the competitor landscape shifts
- Influence Phase 3 clinical trial design to ensure alignment with key commercial considerations including pricing, access and demand
- Partner with R&D, Regulatory and Corporate Strategy to refresh target product profile (TPPs)
- Identify and mitigate key commercial risks ahead of Phase 3 investment decisions
- Conduct market research to assess drivers of physician adoption and patient access
Launch Planning
- Partner with CCO to build an integrated launch plan, including a detailed commercial launch plan inclusive of commercial resourcing and organizational design
- Identify and partner with external partners who can support commercial launch preparation
Forecasting & Analytics
- Lead commercial forecasting and scenario modeling, incorporating market access dynamics, competitive landscape, and adoption assumptions
- Partner with Finance team to conduct ROI assessments to aid with portfolio prioritization and launch sequencing strategy
External Engagement
- Generate insights through engagement with payers, KOLs, and advisors
- Partner with Medical team to execute cross-functional KOL engagement plan
Cross-Functional Leadership
- Serve as the commercial lead on Spyre Product Teams
- Ensure alignment between development strategy and commercial success factors
- Contribute to Board and investor materials
- Engage with potential strategics and represent commercial voice in discussions
Team Leadership
- Identify and recruit top talent to join commercial organization as the team grows
- Lead, develop and mentor future direct reports
- Other duties as assigned
Ideal Candidate:
- 12+ years of experience in biotech/pharma across market access, commercial strategy, and/or marketing
- Demonstrated experience developing biotech/pharma commercial and access strategy for assets in Phase 2 and Phase 3 development
- Commercial launch and/or in-line experience, in market access and/or marketing
- Expertise partnering with R&D, Medical and Regulatory to develop value maximizing Phase 3 designs and TPPs
- Deep understanding of global payer dynamics, pricing strategy, and patient access/services
- Experience in commercial forecasting and strategic planning
- Experience building commercial and cross-functionally integrated launch plans
- Track record of successfully influencing across functions
- Excellent communication skills with the proven ability to work effectively in a fast-paced environment
What We Offer:
- Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
- Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
- Unlimited PTO
- Two, one-week company-wide shutdowns each
- Commitment to provide professional development opportunities.
- Remote working environment with frequent in-person meetings to address complex problems and build relationships.
The expected salary range offer for this role is $330,000 to $357,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.
As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.
Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.
Please also be aware that all job postings will be listed on our website at spyre.com/careers/.