Johnson & Johnson Innovative Medicine is recruiting for Principal Data Scientist – R&D DSDH - Preclinical Sciences & Translational Safety (PSTS). The primary location for this position is open to Spring House, PA; Titusville, NJ; Cambridge, MA; San Diego, CA; Beerse, Belgium; Madrid, Spain; or Barcelona, Spain.
Position Summary
The R&D Data Science organization is seeking a Data Scientist to leverage advanced machine learning, robust data engineering techniques, and domain expertise to drive impactful decisions and generate actionable insights within the Pharmaceutical Sciences & Translational Safety (PSTS) organization. In this role, you will work closely with multidisciplinary teams—including toxicologists, PK/PD specialists, in vivo researchers, and safety professionals—to create AI‑ready datasets, develop predictive models, and deliver analytical solutions that promote improved safety evaluations and facilitate translational research.
Key Responsibilities Develop and deploy ML/AI models to support safety signal detection, dose selection, PK/PD modeling, toxicology insights, and translational interpretation. Implement representation‑learning, predictive modeling, and multivariate analytics for datasets spanning in vivo studies, in vitro assays, exposure‑response data, and pathology information. Partner with scientific SMEs to design modeling strategies aligned with PSTS decision points. Apply model governance, versioning, and validation standards consistent with R&D AI practices. Build and maintain scalable data pipelines that integrate PSTS‑relevant data sources. Transform raw experimental outputs into standardized, analysis‑ready, AI‑ready datasets using Python, R, and cloud‑native services. Contribute to harmonized scientific data models in collaboration with data engineering and ontology teams. Work directly with toxicology, DMPK, and safety stakeholders to interpret scientific context and translate study designs into computational requirements. Apply understanding of mechanism‑based toxicology, exposure‑response concepts, and in vivo study structures to guide data transformations and modeling strategies. Enhance cross‑study comparability via standardized terminologies, metadata practices, and quality checks. Collaborate with PSTS functional experts, R&D Data Science teams, and platform architects to ensure high‑quality, scalable data solutions. Qualifications
Required
Advanced degree (MS or PhD) in Data Science, Computational Biology, Toxicology, Pharmacology, Biomedical Engineering, Computer Science, or related field. 3+ years of experience applying machine learning and/or data engineering to scientific or biomedical datasets. Proficiency with Python and/or R, SQL, and modern data engineering tooling (cloud computing, workflow orchestration, version control). Experience with ML model development, evaluation, and deployment pipelines. Experience working with biological, toxicology, PK/PD, or in vivo datasets.
Preferred
Experience in safety sciences, ADME/DMPK, toxicogenomics, or biomarker analytics. Familiarity with scientific data formats (e.g., assay outputs, histopathology data, PK time‑course datasets). Exposure to ontologies, semantic technologies, or knowledge graph integration for scientific domains. Experience with cloud‑based data architectures. Understanding of regulatory data standards (e.g., SEND, CDISC). Equal Opportunity Employer
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Salary Range
$117,000.00 – $201,250.00
Benefits Summary
Vacation 120 hours per calendar year. Sick time 40 hours per calendar year (48 in Colorado, 56 in Washington). 13 days of holiday pay. Up to 40 hours of work, personal and family time. Parental leave 480 hours within one year of birth/adoption/foster care. Bereavement leave 240 hours for an immediate family member, 40 hours for an extended family member. Caregiver leave 80 hours. Volunteer leave 32 hours. Military spouse time‑off 80 hours per calendar year. For additional general information on company benefits, visit the website.
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